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Targeting antigens to dendritic cells in vivo

✍ Scribed by Paul J. Tacken; Ruurd Torensma; Carl G. Figdor

Book ID
116569159
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
219 KB
Volume
211
Category
Article
ISSN
0171-2985

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## Abstract The non‐toxic B‐subunit of Shiga toxin (STxB) interacts with the glycolipid Gb~3~, which is preferentially expressed on dendritic cells (DC) and B cells. After administration of STxB chemically coupled to OVA (STxB‐OVA) in mice, we showed that the immunodominant OVA~257–264~ peptide res