Targeted Mutation of the Gene for Cellular Glutathione Peroxidase (Gpx1) Increases Noise-Induced Hearing Loss in Mice

Increased resistance of GPx-1 transgenic

Increased resistance of GPx-1 transgenic mice to tumor promoter–induced loss of glutathione peroxidase activity in skin

✍ Jean-François Bilodeau; Marc-Edouard Mirault 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 French ⚖ 93 KB

Reactive oxygen species formation is strongly suspected to play a role in multistep carcinogenesis, notably in tumor promotion. The tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA) induces peroxide production, oxidative damage to DNA and inflammation in mouse skin. TPA is also known to caus