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Targeted molecular therapy of malignant gliomas

✍ Scribed by Santosh Kesari; Naren Ramakrishna; Claire Sauvageot; Charles D. Stiles; Patrick Y. Wen

Publisher
Springer
Year
2005
Tongue
English
Weight
933 KB
Volume
5
Category
Article
ISSN
1528-4042

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## Abstract Malignant gliomas are relatively uncommon but lethal cancers. Despite recent research efforts in cancer therapy, the prognosis of patients with malignant gliomas has remained dismal. Understanding the molecular pathogenesis of glioma may lead to a rational development of new therapies.

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Hexokinase plays an important role in glucose-utilizing tissues like normal brain and cancers. In these tissues, hexokinase (HK) is mainly bound to mitochondria (mHK). Our objectives were to evaluate total HK (tHK) activity and mHK fraction in gliomas and to determine whether mHK binding could be ta