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Targeted integration of adenovirus vectors in hematopoietic stem cells

✍ Scribed by Hongjie Wang; Pavel Sova; Karol Bomsztyk; Qiliang Li; George Stamatoyannopolous; André Lieber

Book ID
116304524
Publisher
Elsevier Science
Year
2008
Tongue
English
Weight
66 KB
Volume
40
Category
Article
ISSN
1079-9796

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## Abstract ## Background The high affinity Fcγ receptor I (FcγRI; aka CD64) is expressed by dendritic cells (DC) and antigens targeted to this receptor elicit enhanced immune responses. This study was designed to test the hypothesis that targeting an adenoviral (Ad) vector to FcγRI would lead to