𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Targeted for drug delivery

✍ Scribed by Tarek M. Fahmy; Peter M. Fong; Amit Goyal; W. Mark Saltzman


Publisher
Elsevier Science
Year
2005
Tongue
English
Weight
851 KB
Volume
8
Category
Article
ISSN
1369-7021

No coin nor oath required. For personal study only.

✦ Synopsis


The concept of targeted drugs is not new, but dates back to 1906 when Ehrlich 1 first postulated the 'magic bullet'. The durability of this concept is a strong indication of its appeal, but the 'magic bullet' continues to be a challenge to implement in the clinic. The challenge has been on three fronts: finding


πŸ“œ SIMILAR VOLUMES


Rationale for targeted drug delivery
✍ Peter W. Taylor; Colin Howes πŸ“‚ Article πŸ“… 1991 πŸ› Springer 🌐 English βš– 838 KB
Cell adhesion molecules for targeted dru
✍ Alison L. Dunehoo; Meagan Anderson; Sumit Majumdar; Naoki Kobayashi; Cory Berkla πŸ“‚ Article πŸ“… 2007 πŸ› John Wiley and Sons 🌐 English βš– 56 KB
Cell adhesion molecules for targeted dru
✍ Alison L. Dunehoo; Meagan Anderson; Sumit Majumdar; Naoki Kobayashi; Cory Berkla πŸ“‚ Article πŸ“… 2006 πŸ› John Wiley and Sons 🌐 English βš– 371 KB

Rapid advancement of the understanding of the structure and function of cell adhesion molecules (i.e., integrins, cadherins) has impacted the design and development of drugs (i.e., peptide, proteins) with the potential to treat cancer and heart and autoimmune diseases. For example, RGD peptides/pept

Peptide-mediated targeted drug delivery
✍ Sumit Majumdar; Teruna J. Siahaan πŸ“‚ Article πŸ“… 2010 πŸ› John Wiley and Sons 🌐 English βš– 468 KB

## Abstract Targeted drug delivery to specific group of cells offers an attractive strategy to minimize the undesirable side effects and achieve the therapeutic effect with a lower dose. Both linear and cyclic peptides have been explored as trafficking moiety due to ease of synthesis, structural si