METPRC mutations in the ron receptor res
โ
Tracy A. Williams; Paola Longati; Luisa Pugliese; Philippe Gual; Alberto Bardell
๐
Article
๐
1999
๐
John Wiley and Sons
๐
English
โ 218 KB
๐ 1 views
Ron and Met are structurally related receptor tyrosine kinases that elicit a complex biological response leading to invasive growth. Naturally occurring point mutations activate the Met kinase in papillary renal carcinomas (MET PRC mutations). By site-directed mutagenesis, we generated homologous am