Targeted Drug Delivery

✍ Scribed by Rachael W. Sirianni, Bahareh Behkam

• Publisher: Springer US;Humana Press
• Year: 2018
• Tongue: English
• Leaves: 230
• Series: Methods in Molecular Biology 1831
• Edition: 1st ed.
• Category: Library

✦ Synopsis

This volume looks at the latest techniques used to enable therapeutic molecules to be targeted for site-specific delivery. The chapters in this book discuss topics such as approaches to express biologically derived and synthetic nanocarriers; strategies to assist in nanocarrier targeting to specific cells and tissues; and methods for evaluating delivery and efficiency for new classes of agents. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.

Cutting-edge and comprehensive, Targeted Drug Delivery: Methods and Protocols is a valuable resource for anyone interested in understanding the diversity of methods used in this evolving field.

✦ Table of Contents

Front Matter ....Pages i-xi
Front Matter ....Pages 1-1
Synthesis of Cationic Polymer Libraries for Gene Delivery Using Diglycidyl Ethers (Jacob Elmer, Thrimoorthy Potta, Kaushal Rege)....Pages 3-16
Generation of Ultra-Small PLGA Nanoparticles by Sequential Centrifugation (Xingwang Wu, Jiangbing Zhou, Toral R. Patel)....Pages 17-24
Construction of Bacteria-Based Cargo Carriers for Targeted Cancer Therapy (Mahama A. Traore, Ali Sahari, Bahareh Behkam)....Pages 25-35
Production of Extracellular Vesicles Loaded with Therapeutic Cargo (Tek N. Lamichhane, Steven M. Jay)....Pages 37-47
Delivery of Cytotoxic Mesenchymal Stem Cells with Biodegradable Scaffolds for Treatment of Postoperative Brain Cancer (Kevin T. Sheets, Juli R. Bagó, Shawn D. Hingtgen)....Pages 49-58
Nanoparticles for Targeted Drug Delivery to Cancer Stem Cells and Tumor (Hai Wang, Xiaoming He)....Pages 59-67
Front Matter ....Pages 69-69
Exploiting Phage Display for Development of Novel Cellular Targeting Strategies (William Marsh, Amanda Witten, Sarah E. Stabenfeldt)....Pages 71-94
CD44 Targeted Lipid Nanoparticles for MicroRNA Therapy (Stephen L. Hayward, Srivatsan Kidambi)....Pages 95-109
Ultrasound and Microbubble-Mediated Blood-Brain Barrier Disruption for Targeted Delivery of Therapeutics to the Brain (Meaghan A. O’Reilly, Kullervo Hynynen)....Pages 111-119
In Vitro Validation of Targeting and Comparison to Mathematical Modeling (Jill M. Steinbach-Rankins, Michael R. Caplan)....Pages 121-141
Front Matter ....Pages 143-143
Enzyme-Linked Immunosorbent Assay to Quantify Targeting Molecules on Nanoparticles (Rachel S. Riley, Jilian R. Melamed, Emily S. Day)....Pages 145-157
Tunable Collagen Microfluidic Platform to Study Nanoparticle Transport in the Tumor Microenvironment (Matthew R. DeWitt, M. Nichole Rylander)....Pages 159-178
Utilizing the Lung as a Model to Study Nanoparticle-Based Drug Delivery Systems (Dylan K. McDaniel, Veronica M. Ringel-Scaia, Sheryl L. Coutermarsh-Ott, Irving C. Allen)....Pages 179-190
Non-Enzymatic Tissue Homogenization for Biodistribution Analysis (Danielle M. DiPerna, Alesia V. Prakapenka, Eugene P. Chung, Rachael W. Sirianni)....Pages 191-199
Methods and Study Designs for Characterizing the Pharmacokinetics and Pharmacodynamics of Carrier-Mediated Agents (Allison N. Schorzman, Andrew T. Lucas, John R. Kagel, William C. Zamboni)....Pages 201-228
Back Matter ....Pages 229-230

✦ Subjects

Biomedicine; Pharmacology/Toxicology