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Targeted Disruption of the Peroxisomal Fatty Acyl-CoA Oxidase Gene: Generation of a Mouse Model of Pseudoneonatal Adrenoleukodystrophy

✍ Scribed by CHUN-YANG FAN; JIE PAN; RUIYIN CHU; DENISE LEE; KIMBERLY D. KLUCKMAN; NOBUTERU USUDA; INDERJIT SINGH; ANJANA V. YELDANDI; M. SAMBASIVA RAO; NOBUYO MAEDA; JANARDAN K. REDDY


Book ID
111392265
Publisher
John Wiley and Sons
Year
1996
Tongue
English
Weight
921 KB
Volume
804
Category
Article
ISSN
0890-6564

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Acyl-CoA oxidase (Pox1p) is involved in the beta-oxidation of fatty acids and is targeted to the peroxisomal matrix via the use of different signals in various organisms. In rat, mouse and human, Pox1p contains a canonical peroxisomal targeting signal 1 (PTS1), whereas in the yeasts Candida tropical