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Targeted disruption of the mouse ferrochelatase gene producing an exon 10 deletion

✍ Scribed by Scott T. Magness; David A. Brenner


Book ID
117618377
Publisher
Elsevier Science
Year
1999
Tongue
English
Weight
428 KB
Volume
1453
Category
Article
ISSN
0925-4439

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An approach is described to modify yeast artificial chromosomes (YACs) with cassettes that can be easily excised for embryonic stem (ES) cell gene targeting experiments. YAC targeting technology (YTT) uses the WIBR/MIT-820 C57BL/6-mapped YAC library derived from the C57BL/6 mouse as the starting poi