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Targeted disruption of the galectin-3 gene results in decreased susceptibility to multiple low dose streptozotocin-induced diabetes in mice

✍ Scribed by E.P.K. Mensah-Brown; Z. Al Rabesi; A. Shahin; M. Al Shamsi; N. Arsenijevic; D.K. Hsu; F-T Liu; M.L. Lukic

Book ID: 113540695
Publisher: Elsevier Science
Year: 2009
Tongue: English
Weight: 628 KB
Volume: 130
Category: Article
ISSN: 1090-2341
DOI: 10.1016/j.clim.2008.08.024

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To assess genetic factors determining sensitivity to streptozotocin-induced diabetes in inbred strains of mice, a genetic analysis of streptozotocin-sensitive C57BL/6J and streptozotocin-resistant C3H/HeJ mice was performed. One week after a single dose of streptozotocin (200 mg/kg body weight), dif