## Background: We investigated modulation of androgen receptor (ar) activity in prostatic tumor cells by luteinizing hormone-releasing hormone (lhrh)-induced increase of the intracellular cyclic adenosine monophosphate (camp) level. ## Methods: Ar transactivation activity was assessed in transien
โฆ LIBER โฆ
Targeted destruction of androgen-sensitive and -insensitive prostate cancer cells and xenografts through luteinizing hormone receptors
โ Scribed by Carola Leuschner; Frederick M. Enright; Patricia A. Melrose; William Hansel
- Publisher
- John Wiley and Sons
- Year
- 2001
- Tongue
- English
- Weight
- 238 KB
- Volume
- 46
- Category
- Article
- ISSN
- 0270-4137
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Experiments have been performed to clarify whether LHRH agonists might decrease growth of hormone-unresponsive prostate cancer in vivo. Male nude mice were injected s.c. with the human androgen-independent prostate tumor DU 145 cells; osmotic minipumps releasing the LHRH agonist Zoladex (LHRH-A) for