ATP-binding cassette (ABC) transporters are members of a protein superfamily which can be responsible for efflux of drugs from cells of target organisms. In this way, the transporters may provide a mechanism of protection against cytotoxic drugs. In laboratory-generated mutants of fungi, overproduct
Targeted degradation of ABC transporters in health and disease
✍ Scribed by Daphne Nikles; Robert Tampé
- Publisher
- Springer US
- Year
- 2007
- Tongue
- English
- Weight
- 277 KB
- Volume
- 39
- Category
- Article
- ISSN
- 0145-479X
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
The interindividual variation in the rate of drug metabolism and disposition has been known for many years. Pharmacogenomics dealing with heredity and response to drugs is a part of science that attempts to explain variability of drug responses and to search for the genetic basis of such variations
Highly active anti-retroviral therapy (HAART) is used to treat HIV-infected patients and involves administration of multiple antiretroviral drugs acting at different steps of the HIV life cycle. In treating HIV-infected pregnant patients, the aim of therapy is not only to treat the mother but also t