Targeted constitutive activation of signal transducer and activator of transcription 3 in human hepatocellular carcinoma cells by cucurbitacin B
โ Scribed by Meixia Zhang; Hongliang Zhang; Chunyan Sun; Xiaolei Shan; Xiaolin Yang; Jesse Li-Ling; Yihui Deng
- Book ID
- 105992934
- Publisher
- Springer
- Year
- 2008
- Tongue
- English
- Weight
- 585 KB
- Volume
- 63
- Category
- Article
- ISSN
- 0344-5704
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## Abstract Signal transducer and activator of transcription 3 (STAT3) is activated in a variety of human cancers, including ovarian cancer. The molecular mechanism by which the STAT3 is activated in cancer cells is poorly understood. We observed that human ovarian xenograft tumors (A2780) in mice
## Abstract Numerous reports suggest that interleukinโ6 (ILโ6) promotes survival and proliferation of tumor cells through the phosphorylation of a cellโsignaling protein, signalโtransducerโandโactivatorโofโtranscriptionโ3 (STAT3). Constitutive activation of STAT3 in head and neck squamous cell carc