A novel nanocrystal formulation of hydrophobic drugs has been developed for cancer therapy. The new method, called a three-phase nanoparticle engineering technology (3PNET), includes three phases: phase 1, amorphous precipitate; phase 2, hydrated amorphous aggregate; and phase 3, stabilized nanocrys
✦ LIBER ✦
Targeted cancer therapy with novel high drug-loading nanocrystals
✍ Scribed by Liu, Feng (author);Park, Ji Young (author);Zhang, Yong (author);Conwell, Christine (author);Liu, Yang (author);Bathula, Surendar Reddy (author);Huang, Leaf (author)
- Publisher
- John Wiley and Sons Inc.
- Year
- 2010
- Tongue
- English
- Weight
- 235 KB
- Volume
- 99
- Category
- Article
- ISSN
- 0022-3549
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## Abstract Twenty previously synthesized fused heterocyclic DNA‐topoisomerase II (Topo II)‐inhibiting compounds were investigated for their potential efficacy in various human cancer cell lines that were derived from different tumor entities. Moreover, different multidrug‐resistant variants of the