## Abstract The unique therapeutic value of dendritic cells (DCs) for the treatment of allergy, autoimmunity and transplant rejection is predicated upon our ability to selectively deliver antigens, drugs or nucleic acids to DCs in vivo. Here we describe a method for delivering whole protein antigen
✦ LIBER ✦
Targeted antigen delivery to antigen–presenting cells including dendritic cells by engineered Fas-mediated apoptosis
✍ Scribed by Weiner, David B.; Chattergoon, Michael A.; Kim, J. Joseph; Yang, Joo-Sung; Robinson, Tara M.; Lee, Daniel J.; Dentchev, Tzvete; Wilson, Darren M.; Ayyavoo, Velpandi
- Book ID
- 109828961
- Publisher
- Nature Publishing Group
- Year
- 2000
- Tongue
- English
- Weight
- 298 KB
- Volume
- 18
- Category
- Article
- ISSN
- 1087-0156
- DOI
- 10.1038/79470
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## Abstract Dendritic cell (DC)‐based vaccines have become important in immunotherapeutics as a measure for generating antitumor immune responses. We have previously demonstrated that linkage of the antigen gene to a lysosomal targeting signal, a sorting signal of the lysosome‐associated membrane p