Notch signaling as a therapeutic target
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Yunsun Nam; Jon C Aster; Stephen C Blacklow
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Article
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2002
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Elsevier Science
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English
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Signals transduced by Notch receptors influence differentiation and proliferation in a wide variety of cell types. Activation of a Notch signal by one of several ligands triggers a series of proteolytic cleavages that release the intracellular region of Notch from the membrane, allowing it ultimatel