Target-derived BDNF (brain-derived neurotrophic factor) is essential for the survival of developing neurons in the isthmo-optic nucleus

Up-regulation of brain-derived neurotrop

Up-regulation of brain-derived neurotrophic factor by application of fibroblast growth factor-2 to the cut optic nerve is important for long-term survival of retinal ganglion cells

✍ Rosa E. Blanco; Ileana Soto; Mildred Duprey-Díaz; Jonathan M. Blagburn 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 English ⚖ 660 KB

## Abstract Application of basic fibroblast growth factor (FGF‐2) to the optic nerve after axotomy promotes the survival of retinal ganglion cells (RGCs) in the frog __Rana pipiens__ and results in a rapid up‐regulation of brain‐derived neurotrophic factor (BDNF) and TrkB synthesis by the RGCs. Her