The tyrosine kinase TrkB is a receptor for the neurotrophic factors brain-derived neurotrophic factor (BDNF) and neurotrophin-4 (NT-4). Retinal ganglion cells are responsive to BDNF, and TrkB has been localized in ganglion cells as well as in a subpopulation of amacrine cells in the retina of the ch
Target-derived and locally derived neurotrophins support retinal ganglion cell survival in the neonatal rat retina
โ Scribed by Spalding, Kirsty L. ;Rush, Robert A. ;Harvey, Alan R.
- Publisher
- John Wiley and Sons
- Year
- 2004
- Tongue
- English
- Weight
- 159 KB
- Volume
- 60
- Category
- Article
- ISSN
- 0022-3034
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
To understand the intimate axon-Schwann cell relationship required for the accurate development and regeneration of the peripheral nervous system (PNS), it is important to elucidate the repertoire of growth factors involved in this tightly regulated bi-directional dialogue. We focused on the identif
Adult rat retinal ganglion cells (RGC) undergo degeneration after optic nerve transection. Studies have shown that exogenously applied neurotrophic factors such as brain-derived neurotrophic factor (BDNF) can attenuate axotomy-induced as well as developmental RGC death. Here, we examined whether gli