“Target” cells, cellular phenotypes, and lineage fidelity in human leukaemia

✍ Scribed by Melvyn F. Greaves

• Book ID: 102882294
• Publisher: John Wiley and Sons
• Year: 1982
• Tongue: English
• Weight: 1002 KB
• Volume: 113
• Category: Article
• ISSN: 0021-9541
• DOI: 10.1002/jcp.1041130418

✦ Synopsis

A detailed analysis of lymphoid leukaemia cells with a panel of monoclonal antibodies plus other markers indicates a striking conservation of phenotype that closely mimics that of normal lymphoid precursor or progenitor cells and reflects the imposition of maturation arrest. The composite phenotypes detected show some minimal deviations or asynchronies (with respect to maturation "stages") but are faithful with respect to cell lineage. These observations are suggested to shed light on the available "target" populations for lymphoid malignancy in humans and challenge the view that dedifferentiation or qualitatively aberrant gene expression i s common and important in malignancy. They are further taken to support the view that normal gene products that regulate or couple proliferation and maturation are critically involved in the successive clonal selection events underlying