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Tardive dyskinesia correlates inversely with polydipsia in chronic psychiatric patients

✍ Scribed by Tadashi Nishikawa; Kohji Katayanagi; Akira Tsuda; Itsuyuki Koga; Yasunori Uchida; Teruo Hayashi; Haruo Tominaga; Masatoshi Tanaka


Publisher
John Wiley and Sons
Year
1998
Tongue
English
Weight
69 KB
Volume
13
Category
Article
ISSN
0885-6222

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✦ Synopsis


The present study was undertaken to investigate the relationship between tardive dyskinesia (TD) and polydipsia. The Abnormal Involuntary Movement Scale (AIMS) and percent of maximum weight gain (PMWG)/week were simultaneously examined in 163 hospitalized patients receiving neuroleptic treatment. Patients with TD were less polydipsic than patients without TD. Moreover, there was a weak but signi®cant negative correlation between the AIMS total scores and PMWG. The AIMS total scores were correlated signi®cantly with age at onset of disease, whereas PMWG was negatively correlated with age at disease onset. The present study is the ®rst report to clarify the relationship between TD and polydipsia utilizing continuous data of both TD and polydipsia. The biological bases of the dierence between TD and polydipsia were discussed in term of supersensitivity of dopaminergic and noradrenergic neurons.


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