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TaqMan real-time PCR quantification strategy of CYP2D6 gene copy number for the LightCycler 2.0

✍ Scribed by Duc L. Nguyen; Julia Staeker; Barbara Laika; Werner Steimer


Book ID
116348251
Publisher
Elsevier Science
Year
2009
Tongue
English
Weight
363 KB
Volume
403
Category
Article
ISSN
0009-8981

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The genetic polymorphism of the cytochrome P450 monooxygenase, CYP2D6, comprises at least 43 alleles giving rise to distinct drug metabolism phenotypes termed ultrarapid, extensive, intermediate, and poor metabolizers. As a consequence, drug side effects or lack of drug effect may occur if standard