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TAP1-dependent peptide translocation in vitro is ATP dependent and peptide selective

✍ Scribed by James C. Shepherd; Ton N.M. Schumacher; Philip G. Ashton-Rickardt; Suguru Imaeda; Hidde L. Ploegh; Charles A. Janeway Jr.; Susumu Tonegawa


Book ID
119064299
Publisher
Elsevier Science
Year
1993
Tongue
English
Weight
768 KB
Volume
74
Category
Article
ISSN
0092-8674

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## Abstract Fetal thymic organ cultures of N15‐transgenic RAG‐2^–/–^ H‐2^b^ mice on normal, β‐2 microglobulin (Ξ²2M)^–/–^ or transporter associated with antigen processing (TAP‐1)^–/–^ MHCI‐deficient backgrounds were used to examine differentiation of thymocytes bearing a TCR specific for a viral pe