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Tanshinone IIA suppresses inflammatory bone loss by inhibiting the synthesis of prostaglandin E2 in osteoblasts

✍ Scribed by Han Bok Kwak; Hyun-Min Sun; Hyunil Ha; Ha-Neui Kim; Jong-Ho Lee; Hong-Hee Kim; Hong-In Shin; Zang Hee Lee


Book ID
113587936
Publisher
Elsevier Science
Year
2008
Tongue
English
Weight
664 KB
Volume
601
Category
Article
ISSN
0014-2999

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## Abstract We previously reported that prostaglandin F~2Ξ±~ (PGF~2Ξ±~) induces phosphoinositide hydrolysis by phospholipase C and phosphatidylcholine hydrolysis by phospholipase D through heterotrimeric GTP‐binding protein, resulting in the activation of protein kinase C (PKC) in osteoblast‐like MC3