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Tandem Michael imino–aldol reactions catalyzed by samarium diiodide
✍ Scribed by Nada Jaber; Jean-Claude Fiaud; Jacqueline Collin
- Publisher
- Elsevier Science
- Year
- 2001
- Tongue
- French
- Weight
- 60 KB
- Volume
- 42
- Category
- Article
- ISSN
- 0040-4039
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📜 SIMILAR VOLUMES
Samarium diiodide catalyzes a one pot procedure allowing to perform sequentially the Mukaiyama-Michael addition of a ketene silyl acetal on a cyclic ~,~-unsaturated ketone, followed by a Mukaiyama aldol reaction of an aldehyde. The adducts are isolated as silyl ethers in good yields and in most case
In the presence of a catalytic amount of samarium diiodide in methylene chloride, aromatic imines react with Danishefsky diene to form tetrahydropyridine-4-ones in high yields. Under the same conditions, various imino-aldol reactions afford b-amino esters or b-amino ketones.