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Tandem Michael-Addition/Cyclization Synthesis and EGFR Kinase Inhibition Activity of Pyrido[2,3-d]pyrimidin-7(8H)-ones.

✍ Scribed by Eric E. Boros; Edgar R. Wood; O. Bradley McDonald; Timothy D. Spitzer; Andrea M. Sefler; Bryan R. Reep; James B. Thompson


Publisher
John Wiley and Sons
Year
2004
Weight
24 KB
Volume
35
Category
Article
ISSN
0931-7597

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Abstract

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Tandem Michael-addition/cyclization synt
✍ Eric E. Boros; James B. Thompson; Edgar R. Wood; O. Bradley McDonald; Timothy D. 📂 Article 📅 2004 🏛 Journal of Heterocyclic Chemistry 🌐 English ⚖ 136 KB

## Abstract 5‐Methoxy and 5‐anilinopyrido[2,3‐__d__]pyrimidin‐7(8__H__)‐ones **2a‐2f** were obtained by a tandem Michael addition‐cyclization reaction of methanol and anilines with pyrimidinylpropynoate **5.** Methoxy derivative **2a** was obtained in 62% yield by treatment of **5** with methanol a