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Tandem mass spectrometry in vitamin E analysis

✍ Scribed by Terence J. Walton; Carol J. Mullins; Russell P. Newton; A. Gareth Brenton; John H. Beynon

Publisher
John Wiley and Sons
Year
1988
Tongue
English
Weight
436 KB
Volume
16
Category
Article
ISSN
1076-5174

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✦ Synopsis

Tandem mass spectrometry is applied to the tocopherols and representative tocotrienols of the vitamin E family. The collision-induced dissociation/mass analysed ion kinetic energy spectra generated from three ions in the electron impact ionization spectra of 5,7,&trimethyltocol, 5,7,&trimethyltocotrienol, 57-, 5 , s and 7,&dimethyltocol and 7,gdimethyltocotrienol are described. The technique allowed direct physical characterization of each class of tocochromanol, and in the case of monomethyltocols differentiation of 5-methyltocol from the 7-and &methyltocol isomers, and its value in analysis of biological tissue extracts is established.

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✍ C. Lauridsen; S.W. Leonard; D.A. Griffin; D.C. Liebler; T.D. McClure; M.G. Trabe 📂 Article 📅 2001 🏛 Elsevier Science 🌐 English ⚖ 104 KB

A method for quantification of unlabeled alpha-tocopherol and the deuterated tocopherols, RRR-alpha-5-(CD(3))-tocopherol (d(3)RRR) and all rac-alpha-5,7-(CD(3))(2) tocopherol (d(6)all-rac) in plasma by HPLC-tandem mass spectrometry (LC-MS/MS) has been developed. Deuterated and unlabeled alpha-tocoph