𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Tandem mass spectrometric studies of the fragmentation of penicillins and their metabolites

✍ Scribed by Somchai Suwanrumpha; Donald A. Flory; Royal B. Freas; Marvin L. Vestal

Publisher
John Wiley and Sons
Year
1988
Tongue
English
Weight
517 KB
Volume
16
Category
Article
ISSN
1076-5174

No coin nor oath required. For personal study only.

✦ Synopsis

The fragmentation of two penicillins, ampicillin and amoxiciin, and their principal metabolites has been studied by a combination of liquid cbromatogrephy/thermospny mass spectrometry and tandem mass spectrometry. A high-resolution tandem mass spectrometer was used to obtain chemical ionization, fast-atom bombardment, and collision-induced dissociation mass spectra Structural information and fragmentation mechanisms have been deduced from ions in the mass and collision spectra. This knowledge is useful in the analysis and identification of metabolites of ampicillin and related drugs in human body fluids.

πŸ“œ SIMILAR VOLUMES

Electrospray tandem mass spectrometric s
Electrospray tandem mass spectrometric studies of phosphopeptides and phosphopeptide analogues
✍ Tholey, Andreas; Reed, Jennifer; Lehmann, Wolf D. πŸ“‚ Article πŸ“… 1999 πŸ› John Wiley and Sons 🌐 English βš– 284 KB πŸ‘ 2 views

A set of synthetic phosphopeptides and phosphopeptide analogues was studied by tandem nano-electrospray mass spectrometry. The inΓ‘uence of the collision o †set and of the charge state of the molecular ion on phosphate-speciÐc fragmentation processes was investigated in detail. H-D exchange experimen