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Tandem Asymmetric Cyclopropanation/Cope Rearrangement. A Highly Diastereoselective and Enantioselective Method for the Construction of 1,4-Cycloheptadienes

✍ Scribed by Davies, Huw M. L.; Stafford, Douglas G.; Doan, Brian D.; Houser, Jeffrey H.


Book ID
115472779
Publisher
American Chemical Society
Year
1998
Tongue
English
Weight
259 KB
Volume
120
Category
Article
ISSN
0002-7863

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Strategy for the Construction of Functionalized Five-and Six-Membered Carbocycles. -Conjugate addition of the Grignard reagents (II) and (IV) to the nitro olefins (I) leads to the intermediate formation of nitronates, which are trapped as silyl nitronates and subsequently cyclized by intramolecular