Tampering with the cell cycle's brakes
β Scribed by Brooksbank, Cath
- Book ID
- 109771400
- Publisher
- Nature Publishing Group
- Year
- 2000
- Tongue
- English
- Weight
- 317 KB
- Volume
- 1
- Category
- Article
- ISSN
- 1471-0072
- DOI
- 10.1038/35040034
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Precise control of cell-cycle progression is believed to be critical for normal development, while oncogenesis may be a direct result of its disturbance. Cellcycle progression is regulated predominantly by a series of serine/threonine kinases, the cyclin-dependent kinases (CDKs). The activities of t
## Abstract A prominent role for the execution of cell cycle and growth regulatory mechanisms within the threeβdimensional context of nuclear architecture is becoming increasingly evident. Signaling pathways and regulatory networks that govern activation and suppression of genes controlling prolife