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Tamoxifen reduces P-gp-mediated multidrug resistance via inhibiting the PI3K/Akt signaling pathway in ER-negative human gastric cancer cells

✍ Scribed by Mao, Zonglei; Zhou, Jin; Luan, Junwei; Sheng, Weihua; Shen, Xiaochun; Dong, Xiaoqiang


Book ID
121340179
Publisher
Elsevier Science
Year
2014
Tongue
English
Weight
727 KB
Volume
68
Category
Article
ISSN
0753-3322

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## Abstract We observed that treatment of prostate cancer cells for 24 h with magnolol, a phenolic component extracted from the root and stem bark of the oriental herb __Magnolia officinalis__, induced apoptotic cell death in a dose‐ and time‐dependent manner. A sustained inhibition of the major su