Tamoxifen modulation of cisplatin cytotoxicity in human malignancies

✍ Scribed by Edward F. McClay; Kathleen D. Albright; Jeffrey A. Jones; Randolph D. Christen; Stephen B. Howell

• Book ID: 102277167
• Publisher: John Wiley and Sons
• Year: 1993
• Tongue: French
• Weight: 479 KB
• Volume: 55
• Category: Article
• ISSN: 0020-7136
• DOI: 10.1002/ijc.2910550623

✦ Synopsis

Recent clinical trials have indicated that addition of tamoxifen (TAM) to a combination of cisplatin (DDP), carmustine and dacarbazine markedly increases the overall objective response rate of patients with metastatic malignant melanoma. Previous studies have determined that there is remarkable synergy between TAM and DDP in a human melanoma cell line T-289.

Using the technique of median effect analysis, in clonogenic assay, we observed a highly synergistic interaction between TAM and DDP. To determine whether or not this synergistic