Tamoxifen induces masculinization of genetic females and regulates P450 aromatase and müllerian inhibiting substance mRNA expression in Japanese flounder (Paralichthys olivaceus)

Aromatase inhibitor and 17α-methyltestos

Aromatase inhibitor and 17α-methyltestosterone cause sex-reversal from genetical females to phenotypic males and suppression of P450 aromatase gene expression in Japanese flounder (Paralichthys olivaceus)

✍ Takeshi Kitano; Kazufumi Takamune; Yoshitaka Nagahama; Shin-Ichi Abe 📂 Article 📅 2000 🏛 John Wiley and Sons 🌐 English ⚖ 250 KB

The sex of Japanese flounder (Paralichthys olivaceus) is easily altered by water temperature or sex steroid hormone treatment during the period of sex determination. We have previously shown that rearing the genetically female larvae at high water temperature caused the suppression of P450 aromatase