Tamoxifen in combination with cytotoxic chemotherapy in advanced epithelial ovarian cancer: A prospective randomized trial
β Scribed by P.E. Schwartz; J.T. Chambers; E.I. Kohorn; S.K. Chambers; H. Weitzman; I.M. Voynick; N. MacLusky; F. Naftolin
- Book ID
- 119053281
- Publisher
- Elsevier Science
- Year
- 1989
- Tongue
- English
- Weight
- 168 KB
- Volume
- 32
- Category
- Article
- ISSN
- 0090-8258
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Fifty-seven evaluable patients with advanced ovarian carcinoma were randomized to receive either a combination of hexamethylmelamine, cyclophosphamide, methotrexate and 5-fluorouracil (Hexa-CAF) or high-dose cyclophosphamide alone given intravenously intermittently. Objective responses were seen in
## Background: Several lines of evidence suggest that the proliferation of ovarian carcinoma might be stimulated by gonadotrophins. a number of phase i/phase ii clinical trials have reported that the suppression of endogenous luteinizing hormone and follicle-stimulating hormone secretion by luteini