Tamoxifen elicits its anti-estrogen effects in growth plate chondrocytes by inhibiting protein kinase C

24R,25-(OH)2D3 mediates its membrane rec

24R,25-(OH)2D3 mediates its membrane receptor-dependent effects on protein kinase C and alkaline phosphatase via phospholipase A2 and cyclooxygenase-1 but not cyclooxygenase-2 in growth plate chondrocytes

✍ Z. Schwartz; V.L. Sylvia; F. Del Toro; R.R. Hardin; D.D. Dean; B.D. Boyan 📂 Article 📅 2000 🏛 John Wiley and Sons 🌐 English ⚖ 308 KB 👁 1 views

Recent studies have shown that 24R,25-(OH) 2 D 3 mediates its effects on growth plate chondrocytes via membrane receptors. This study examined the roles of phospholipase A 2 (PLA 2 ) and cyclooxygenase (Cox) in the mechanism of action of 24R,25-(OH) 2 D 3 in resting zone chondrocytes in order to det