Rap1 controls activation of the Ξ±MΞ²2 int
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Jenson Lim; AurΓ©lien G. Dupuy; David R. Critchley; Emmanuelle Caron
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Article
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2010
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John Wiley and Sons
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English
β 386 KB
The small GTPase Rap1 and the cytoskeletal protein talin regulate binding of C3bi-opsonised red blood cells (RBC) to integrin a M b 2 in phagocytic cells, although the mechanism has not been investigated. Using COS-7 cells transfected with a M b 2 , we show that Rap1 acts on the b 2 and not the a M