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Takaneones A–C, prenylated butylphloroglucinol derivatives from Hypericum sikokumontanum

✍ Scribed by Naonobu Tanaka; Yoshiki Kashiwada; Michiko Sekiya; Yasumasa Ikeshiro; Yoshihisa Takaishi

Publisher
Elsevier Science
Year
2008
Tongue
French
Weight
128 KB
Volume
49
Category
Article
ISSN
0040-4039

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✦ Synopsis

Three new prenylated butylphloroglucinol derivatives, takaneones A-C (1-3), were isolated from the MeOH extracts of the aerial parts of Hypericum sikokumontanum together with two new prenylated phloroglucinol derivatives, takaneols A and B (4 and 5). The structures of the isolated compounds were elucidated by exhaustive spectroscopic analysis. The cytotoxicities of the isolated compounds against human cancer cell lines were evaluated. Compounds 2-4 showed cytotoxicities against K562/Adr multi-drug resistant (MDR) cancer cells with IC 50 values ranging from 4.7 to 10.0 lg/mL, which were slightly more potent than doxorubicin. Their potency of cytotoxicities against MDR cancer cell lines (KB-C2 and K562/Adr) were similar to those against sensitive cell lines (KB and K562).

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ChemInform Abstract: Takaneones A—C, Pre
ChemInform Abstract: Takaneones A—C, Prenylated Butylphloroglucinol Derivatives from Hypericum sikokumontanum.
✍ Naonobu Tanaka; Yoshiki Kashiwada; Michiko Sekiya; Yasumasa Ikeshiro; Yoshihisa 📂 Article 📅 2008 🏛 John Wiley and Sons ⚖ 27 KB 👁 1 views

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