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Tailored strategy for AML patients receiving allogeneic peripheral blood stem cell transplantation

✍ Scribed by Sang Kyun Sohn; Jong Gwang Kim; Dong Hwan Kim

Publisher
John Wiley and Sons
Year
2006
Tongue
English
Weight
367 KB
Volume
21
Category
Article
ISSN
0733-2459

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✦ Synopsis

Considering the heterogeneity of acute myelogenous leukemia (AML), along with the pros and cons of allogeneic peripheral blood stem cell transplantation (PBSCT), a tailored strategy is needed to minimize the transplant-related mortality and maximize the transplant outcomes in AML patients exhibiting certain factors that have an impact on the post-transplant quality of life and outcomes. The factors that need to be considered when tailoring a strategy in an allogeneic PBSCT setting include the recipient's performance status and co-morbid disease include AML risk stratification, disease status, expected severity of graft-versus-host disease, and the necessity of a graft-versus-leukemia effect. Accordingly, this review article describes a possible tailoring strategy for AML patients receiving allogeneic PBSCT based on certain factors influencing the transplant outcome.

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