## Abstract Caseβcontrol studies provide an important epidemiological tool to evaluate candidate genes. There are many different study designs available. We focus on a more recently proposed design, which we call a multiplex caseβcontrol (MCC) design. This design compares allele frequencies between
Tag SNP selection for candidate gene association studies using HapMap and gene resequencing data
β Scribed by Xu, Zongli; Kaplan, Norman L; Taylor, Jack A
- Book ID
- 110027075
- Publisher
- Nature Publishing Group
- Year
- 2007
- Tongue
- English
- Weight
- 125 KB
- Volume
- 15
- Category
- Article
- ISSN
- 1018-4813
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
## Abstract Modern molecular techniques make discovery of numerous single nucleotide polymorphims (SNPs) in candidate gene regions feasible. Conventional analysis relies on either independent tests with each variant or the use of haplotypes in association analysis. The first technique ignores the d
## Communicated by Graham R. Taylor Colorectal cancer (CRC) is a multifactorial disease that involves both lifestyle and genetic factors. To identify single nucleotide polymorphisms (SNPs) associated with sporadic CRC, we used pooled DNA samples representing 230 cases with sporadic CRC and 540 con
## Abstract Few comparison studies have been performed on single nucleotide polymorphism (SNP) tagging methods to examine their consistency and effectiveness in terms of inferences about association with disease. We applied several SNP tagging methods to SNPs on chromosome 12q (__n__=713) and compa