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Tacrolimus potently inhibits human osteoclastogenesis induced by IL-17 from human monocytes alone and suppresses human Th17 differentiation

โœ Scribed by Toru Yago; Yuki Nanke; Manabu Kawamoto; Hisashi Yamanaka; Shigeru Kotake


Book ID
116400639
Publisher
Elsevier Science
Year
2012
Tongue
English
Weight
741 KB
Volume
59
Category
Article
ISSN
1043-4666

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## Abstract ILโ€17 is a proinflammatory cytokine crucial for osteoclastic bone resorption in the presence of osteoblasts or synoviocytes in rheumatoid arthritis. However, the role of ILโ€17 in osteoclastogenesis from human monocytes alone remains unclear. Here, we investigated the role of ILโ€17 in os