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Tacrolimus (FK506) suppresses rt-PA-induced hemorrhagic transformation in a rat thrombotic ischemia stroke model

✍ Scribed by Masashi Maeda; Yasuhisa Furuichi; Takahisa Noto; Nobuya Matsuoka; Seitaro Mutoh; Yukio Yoneda

Book ID
113504008
Publisher
Elsevier Science
Year
2009
Tongue
English
Weight
470 KB
Volume
1254
Category
Article
ISSN
0006-8993

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## Abstract We evaluated a role of hypoxia‐inducible factor‐1α (HIF‐1α) and its downstream genes in acute hyperglycemia‐induced hemorrhagic transformation in a rat model of focal cerebral ischemia. Male Sprague‐Dawley rats weighing 280–300 g (n = 105) were divided into sham, 90 min middle cerebral