Tachykinin NK2 receptors and enhancement of cholinergic transmission in the inflamed rat colon: an in vivo motility study
β Scribed by F Carini; A Lecci; M Tramontana; S Giuliani; C A Maggi
- Book ID
- 110005782
- Publisher
- Nature Publishing Group
- Year
- 2001
- Tongue
- English
- Weight
- 209 KB
- Volume
- 133
- Category
- Article
- ISSN
- 0007-1188
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## Abstract The sulphated octapeptide Cβterminal fragment of cholecystokinin (CCKβ8s) is present in high concentration in the mammalian brain, where it acts via two types of receptor denoted CCK~A~, and CCK~B~. In the dorsal hippocampus, CCKβ8S exerts a potent excitatory effect on pyramidal neurons
In this study, we examined the effect of the acute and chronic administration of the selective neurokinin 2 (NK 2 ) receptor antagonist SR 48968 on the activity of spontaneously active dopamine (DA) cells in the substantia nigra pars compacta (SNC) and ventral tegmental area (VTA) in anesthetized, m