tability Indicating Method for the Analysis of Nicotine in Transdermal Drug Delivery Systems by Means of Gas Chromatography

✍ Scribed by Klaffenbach, Peter ;Kronenfeld, Detlev ;Peterson, Timothy A.

• Publisher: John Wiley and Sons
• Year: 1998
• Tongue: English
• Weight: 52 KB
• Volume: 21
• Category: Article
• ISSN: 0935-6304
• DOI: 10.1002/(sici)1521-4168(19981201)21:12<649::aid-jhrc649>3.0.co;2-r

✦ Synopsis

The delivery of drugs through human skin using transdermal drug delivery (TDD) systems has become an established technology. A popular drug with that dosage form is nicotine for smoking cessation. A stability indicating method for the analysis of nicotine TDDs using gas chromatography (GC) with post-column effluent splitting to a flame ionization detector (FID) and a nitrogen-phosphorus detector (NPD) is described. FID detection gave reliable results with low dayto-day variability. The detector is relatively simple to operate. NPD detection offered enhanced sensitivity and specificity. The combination of both detectors resulted in a rugged method for content analysis with high sensitivity for detection of degradation products at low concentration levels. Despite a relatively simple sample preparation procedure no matrix interferences were observed.