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T2013 Galectin-3 Sequence Polymorphisms Predict Response of Colon Cancer Cells to Chemotherapy

✍ Scribed by Mazurek, Nachman; Ueno, Suguru; Sun, Yun Jie; Byrd, James C.; Bresalier, Robert S.


Book ID
122397405
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
49 KB
Volume
138
Category
Article
ISSN
0016-5085

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## Abstract Thymidylate synthase (TS) is the primary target of 5‐fluorouracil (5‐FU). A VNTR polymorphism in the TS promoter region is associated with the efficacy of 5‐FU‐based chemotherapy in colorectal cancer. A common G>C SNP at the 12th nucleotide of the second repeat in the TS\*3 alleles has