T2* effects in the dual-sequence method for high-dose first-pass myocardial perfusion
✍ Scribed by Peter Gatehouse; Jonathan Lyne; Gillian Smith; Dudley Pennell; David Firmin
- Publisher
- John Wiley and Sons
- Year
- 2006
- Tongue
- English
- Weight
- 228 KB
- Volume
- 24
- Category
- Article
- ISSN
- 1053-1807
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✦ Synopsis
Abstract
Purpose
To examine whether T2* effects reduce the accuracy of arterial input function (AIF) measurement by the dual‐sequence method.
Materials and Methods
The dual‐sequence method obtains a low‐resolution AIF image and high‐resolution myocardial images in each cycle, with suitable T1 weightings. It was modified to assess T2* effects in the low‐resolution AIF image (4.8 × 4.8 × 10 mm voxels, TE = 0.58 msec) by minimizing T1 weighting in that sequence, while the myocardial sequence remained T1‐weighted. In 10 patients who underwent perfusion MRI scans (0.5 M Magnevist, 0.1 mmol/kg, 15‐ml flush, 7 mL/second right antecubital) the blood signal in the left ventricle (LV) was measured at the bolus peak and compared with the first cycle's fresh magnetization signal.
Results
The bolus peak measured 98% ± 4% (mean ± SD, N = 20) of the value before contrast agent arrival.
Conclusion
T2* causes insignificant error in the dual‐sequence method at the stated parameters. J. Magn. Reson. Imaging 2006. © 2006 Wiley‐Liss, Inc.