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T1856 Tumor Necrosis Factor-α Represses the Na+/H+ Exchanger NHE2 and NHE3 Expression and Function in the Human Intestinal Epithelial Cells

✍ Scribed by Amin, Md Ruhul; Tyagi, Sangeeta; Dudeja, Pradeep K.; Ramaswamy, Krishnamurthy; Malakooti, Jaleh

Book ID
123406657
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
49 KB
Volume
138
Category
Article
ISSN
0016-5085

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✍ Md. Ruhul Amin; Temitope Orenuga; Sangeeta Tyagi; Pradeep K. Dudeja; Krishnamurt 📂 Article 📅 2011 🏛 John Wiley and Sons 🌐 English ⚖ 974 KB

Background: High levels of proinflammatory cytokines are linked to pathogenesis of diarrhea in inflammatory bowel disease (IBD). Na þ absorption is compromised in IBD. The studies were designed to determine the effect of tumor necrosis factor-a (TNFa) on the expression and activity of NHE2, a Na þ /