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T1768 Generation of a Tightly Regulated Doxycycline-Inducible Model for Studying Mouse Intestinal Biology

✍ Scribed by Roth, Sabrina; Franken, Patrick; van Veelen, Wendy; Blonden, Lau; Raghoebir, Lalini; van Drunen, Ellen; Beverloo, H.B.; Kuipers, Ernst J.; Rottier, Robbert; Fodde, Riccardo; Smits, Ron

Book ID: 122809680
Publisher: Elsevier Science
Year: 2009
Tongue: English
Weight: 117 KB
Volume: 136
Category: Article
ISSN: 0016-5085
DOI: 10.1016/S0016-5085(09)62649-4

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Generation of a tightly regulated doxycycline-inducible model for studying mouse intestinal biology

✍ Sabrina Roth; Patrick Franken; Wendy van Veelen; Lau Blonden; Lalini Raghoebir; 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 456 KB

## Abstract To develop a sensitive and inducible system to study intestinal biology, we generated a transgenic mouse model expressing the reverse tetracycline transactivator rtTA2‐M2 under control of the 12.4 kb murine Villin promoter. The newly generated Villin‐rtTA2‐M2 mice were then bred with th