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t(14;18) Translocation: A Predictive Blood Biomarker for Follicular Lymphoma

โœ Scribed by Roulland, S.; Kelly, R. S.; Morgado, E.; Sungalee, S.; Solal-Celigny, P.; Colombat, P.; Jouve, N.; Palli, D.; Pala, V.; Tumino, R.; Panico, S.; Sacerdote, C.; Quiros, J. R.; Gonzales, C. A.; Sanchez, M.-J.; Dorronsoro, M.; Navarro, C.; Barricarte, A.; Tjonneland, A.; Olsen, A.; Overvad, K.; Canzian, F.; Kaaks, R.; Boeing, H.; Drogan, D.; Nieters, A.; Clavel-Chapelon, F.; Trichopoulou, A.; Trichopoulos, D.; Lagiou, P.; Bueno-de-Mesquita, H. B.; Peeters, P. H. M.; Vermeulen, R.; Hallmans, G.; Melin, B.; Borgquist, S.; Carlson, J.; Lund, E.; Weiderpass, E.; Khaw, K.-T.; Wareham, N.; Key, T. J.; Travis, R. C.; Ferrari, P.; Romieu, I.; Riboli, E.; Salles, G.; Vineis, P.; Nadel, B.


Book ID
127335140
Publisher
American Society of Clinical Oncology
Year
2014
Tongue
English
Weight
341 KB
Volume
32
Category
Article
ISSN
0732-183X

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The t( 14; 18) chromosomal translocation characteristic of follicular lymphoma (FL) juxtaposes the immunoglobulin heavy chain locus (IGH) and the BCU proto-oncogene. The translocation can be readily detected as a non-germline Not1 fragment resolved by pulsed-field gel electrophoresis. A benefit of t