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T1283 Association Between the Pregnane-X Receptor Gene and Crohn's Disease Among Children. Results from a Gene-Wide Case-Control and Family-Based Study

✍ Scribed by AMRE, DEVENDRA K.; Mack, David R.; Israel, David M.; Morgan, Kenneth; Krupoves, Alfreda; Costea, Irina C.; Lambrette, Philippe; Deslandres, Colette; Grimard, Guy; Levy, Emile; Seidman, Ernest G.


Book ID
122725809
Publisher
Elsevier Science
Year
2008
Tongue
English
Weight
80 KB
Volume
134
Category
Article
ISSN
0016-5085

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✍ Devendra K. Amre; David R. Mack; David Israel; Kenneth Morgan; Alfreda Krupoves; πŸ“‚ Article πŸ“… 2008 πŸ› John Wiley and Sons 🌐 English βš– 86 KB πŸ‘ 2 views

## Background: The pregnane-X-receptor (PXR) is involved in the metabolism and detoxification of numerous xenobiotics and is critical for maintaining intestinal integrity. The NR1I2 gene encoding PXR may confer susceptibility for Crohn's disease (CD) but evidence for associations is conflicting. We