t(1;19) and t(12;17) in childhood acute lymphoblastic leukemia of pre-B type
โ Scribed by Francesca Ghione; Dorotea Gargano; Carlo Guazzelli; Alma Lippi
- Book ID
- 119103952
- Publisher
- Elsevier Science
- Year
- 1988
- Tongue
- English
- Weight
- 205 KB
- Volume
- 31
- Category
- Article
- ISSN
- 0165-4608
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The t( I; 19) chromosomal translocation in acute lymphoblastic pre-B cell leukemias involves the gene โฌ2A for helix-loop-helix (HLH) proteins E I2 and E47, ubiquitous transcriptional proteins implicated in the regulation of various lymphoid and nonlymphoid genes. To characterize the molecular featur
## Abstract The t(1;19)(q23;p13), which results in a fusion of __TCF3__ (previously __E2A__) at 19p13 with __PBX1__ at 1q23, is one of the most common translocations in acute lymphoblastic leukemia (ALL). It is seen either as a balanced t(1;19) or as an unbalanced der(19)t(1;19); occasional cases w