t(11;19) translocation and CRTC1-MAML2 fusion oncogene in mucoepidermoid carcinoma
✍ Scribed by Iain D. O’Neill
- Book ID
- 113833034
- Publisher
- Elsevier Science
- Year
- 2009
- Tongue
- English
- Weight
- 238 KB
- Volume
- 45
- Category
- Article
- ISSN
- 1368-8375
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## Abstract Translocations and gene fusions have an important early role in tumorigenesis. The t(11;19) translocation and its __CRTC1/MAML2__ fusion transcript have been identified in several examples of both Warthin's tumor and mucoepidermoid carcinoma and are believed to be associated with the de
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## Abstract The present study reports for the first time a __CRTC3‐MAML2__ fusion gene in a mucoepidermoid carcinoma, as determined by RT‐PCR and sequencing. We screened a total of 67 formalin‐fixed, paraffin‐embedded mucoepidermoid carcinomas for the presence of chimeric genes. In one of these sam